![]() MPN Research Foundation: “Stem Cell Transplant for Myelofibrosis,” “Update on Promising MF Treatment, Momelotinib,” “Constellation Pharmaceuticals Provides Update on MANIFEST Clinical Trial of CPI-0610 in Myelofibrosis.” Mayo Clinic: “Myelofibrosis,” “Bone Marrow Transplant.” Called a nonmyeloablative or “mini” transplant, it doesn't call for as much chemotherapy and radiation. Future TreatmentsĪ safer, less intense type of transplant is being studied. If your doctor thinks you’re not healthy enough, they can still treat your symptoms and try to make you comfortable. Your health. You’ll need to be in very good shape to go through a transplant. You’ll fare best if you’re 65 or younger. While older people are most likely to get myelofibrosis, being older means you might not respond well to a stem cell transplant. Depending on what they are and how they're affecting you, your doctor may try to manage your myelofibrosis with medicines rather than a transplant. Your doctor will need to take into account: Candidates for Stem Cell Transplantsīecause of the risks involved, this procedure isn’t a good option for everyone with myelofibrosis. Some people who have a stem cell transplant are more likely to get a different type of cancer later on. This is when the lenses of your eyes get cloudy and affect how well you can see. Your spleen and liver play important roles in getting rid of old or problem red blood cells, so they can be affected by a transplant.Ĭataracts. The new stem cells you get could start to attack your body’s healthy tissue. Most can happen in the first 100 days after your transplant, when your immune system is still weak, but some won’t show up until months, or even years, later. Risks and BenefitsĪ stem cell transplant comes with chances of some serious side effects. You’ll check in often, and they'll do blood tests to check your progress. Your doctor will watch you closely for several weeks or months after the transplant in case you have any problems. It can take about an hour, but you’ll likely need to stay in the hospital a while longer so your medical team can keep a close eye on you.įrequent checkups. Your doctor will put them into your body through a long, thin tube that goes into a large vein in your neck or chest (called a central line). Soon after you finish chemo or radiation, you’ll get your new stem cells. It also weakens your immune system so it’s less likely to attack the new stem cells. Once you’re matched with a donor, you’ll go through at least one type of cancer treatment to get rid of as many cancer cells in your body as possible. Your blood and tissue will have to match that of your donor - this is checked with a blood test or cheek swab.Ĭhemotherapy or radiation. Your doctor also could use umbilical cord blood that was frozen at birth. Many times, this is a sibling or other family member, but you could also search a national donor registry. First, you’ll need to find someone to give you some of their blood cells. Once they're in your body, they can make your immune system stronger and help attack cancer cells.Ī donor match. When you have what’s called an allogeneic stem cell transplant, you get special blood-forming stem cells from a donor. A stem cell transplant is the only treatment that can cure myelofibrosis. Myelofibrosis is a rare kind of blood cancer that keeps your body from making the blood cells you need to be healthy.
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